Background: The etiology of Fever of unknown origin ((FUO)) may differ from different countries. This study was conducted to evaluate the etiology of (FUO) in patients attending SKIMS, a tertiary care teaching hospital, at Srinagar, Kashmir, India.Methods: From July 2010 to September 2012, this study was done to examine the profile of patients with (FUO). The classic (FUO) was defined as three outpatient visits or three days in the hospital without elucidation of cause of Fever. Infectious agents, collagen vascular diseases and hematological malignancies as well as other etiologies were investigated when appropriate. The data were collected and analyzed.Results: A total of 91 cases (62 males and 29 females), with age ranging from 16 to 80 years were investigated. The mean duration of Fever before hospitalization was 26±4 days. The etiology of (FUO) was delineated in (66%) of cases, whereas, (25%) remained undiagnosed. Most common group of (FUO) was that of infectious diseases (44%) followed by collagen vascular diseases and malignancies (12 % each). Amongst the infection group, brucellosis and salmonellosis comprised the majority of cases (25% each).Conclusion: Infections are the most common cause of (FUO) followed by collagen vascular diseases in our region.

Background and purpose: Fever of unknown origin is a frequent disorder in pediatric age.The aim of this study was to determine the causes of Fever of unknown origin and; to evaluate diagnostic tests.Materials and Methods: Cases were identified by reviewing the medical records of all patients with (FUO) which were admitted in three medical centers in Tehran during March 1994- 99.Results: Infection was the most frequent cause of Fever of unknown origin. Neoplastic disorders occurred in children older than one year. Abdominal ultrasonography was performed in 71 patients (61%) and was helpful in diagnosis of 15% of the cases.Conclusion: The improvement in diagnostic procedures has conditioned a change of spectrum of the diseases. In most cases the etiological diagnosis can be made with a limited number of laboratory and/ or imaging investigations bases upon a careful clinical evaluation.

Background: Although infectious diseases are the most common sources for the Fever of unknown origin ((FUO)), but the spectrum of infectious diseases is changing overtime. The purpose of the study was to define the clinical spectrum and changing the pattern of (FUO).Methods: This existing data based study was undertaken from 2007 to 2011. One hundred-six patients fulfilling the modified criteria for (FUO) referred in a teaching hospital in Ahvaz were enrolled for analysis. The data extracted from the patient's medical files and etiologic agents caused (FUO) to be assessed.Results: Infections were the most common cause of (FUO) in 48.4% of the patients. Among the infections, the most important causes of (FUO) were represented by extra-pulmonary tuberculosis 15 (31.9%), osteomyelitis 10 (21.3%) and abdominal abscesses 6 (12.8%).Conclusion: The pattern of (FUO) in the region is thought to be changed to extra pulmonary TB and osteomyelitis. Tuberculosis is still the leading cause of (FUO) in our region.

The causes of Fever of unknown origin are varied with new diagnostic methods and geographical locations. With this aim this study was d7signed on all patients with (FUO) diagnosis who admitted in educational hospital of hamadan city in 1996-2001 .In this study 120 patients who had Fever 'higher than 38.3 C on several occasions persisting without diagnosis for at least 3 weeks in spite of at least 3 days investigation in hospital. or more than 3 visits were known (FUO). In this study infections (60%) have been the commonest cause of (FUO). Miscellaneous causes (15.8%), Neoplasm (10.5%) connective tissue diseases (8.3%) have been the second, third and fourth cause of FUG. Extra pulmonary tuberculosis (20.9%) and Abdominal abscess (19.5%) brucellosis (9.2%) were the most common cause of infectious diseases. Adult still disease, (1.6%) is the most common cause of connective tissue diseases. Lymphoma (3.3%) is the most common causes of neoplasm's. (FUO) is more common in male sex (59.2%) and (FUO) is more common in Patients older than 50 years. Tuberculosis and brucellosis which are two common disease in Hammadan city, are the most common cause of (FUO) too.

Introduction & Objective: Fever of unknown origin ((FUO)) has different etiologies due to new diagnostic procedures and geographic areas. This study aimed to evaluate the patients with (FUO) in hospitals of Shahid Beheshti Universty of Medical Sciences.Materials & Methods: In this survey case series admitted patients with impression of (FUO) in infectious diseases wards of Shahid Beheshti University of Medical Sciences of Iran in 2003 were studied. 52 patients had Fever over 38.3 oC for 3 weeks and their disease was not diagnosed after 3 visits or 3 days of admission.Results: 54% of the patients were male and 46% were female. 85% of the cases were under the age of 60 years. The most common etiology of (FUO) was Infectious diseases (36.5%), and neoplasm (21%), miscellaneous (17.5%), undiagnosed (13.5%), and connective tissue diseases (11.5%) respectively. Tuberculosis (7.7%), Intra-abdominal abscess (7.7%), lymphoma (11.5%), drug Fever (5.8%) and autoimmune hepatitis (3.8%) were the most common infectious diseases.Conclusion: Results of this study are comparable with those in other developing countries and infectious disease is the most common causative agent of (FUO).

Primary cardiac tumors are rare and occur in 1 per 1000 to 1 per 100000 individual in unselected autopsy series at tertiary heart centers .Approximately 75% of cardiac tumors are histologically benign and malignanat cardiac tumors are reminder of them. We describe a rare form of complicated benign cardiac mass in 46 years old man.

A 52-year-old man referred with Fever for 40 days. On examination, he had no abnormal finding except for a slightly enlarged thyroid gland. Thyroid function tests demonstrated a thyrotoxic state with reduced uptake of radioiodine (RAI-U) compatible with subacute thyroiditis (SAT). He had leukocytosis, raised ESR and a painless nontender thyroid gland.

Background: Fever of unknown origin ((FUO)) is a perplexing medical problem. The causes for (FUO) are more than 200 diseases. The aim of the study was to present human clinical cases of Coxiella burnetii infection debuting as (FUO). Methods: The following methods were conducted in the study: literature search, laboratory, imaging, and statistical methods. Criteria of Durack and Street were applied for (FUO) definition. For the etiological diagnosis indirect immunoenzyme assay (ELISA) for antibodies detection against Coxiella burnetii was used (cut-off = 0. 481– 0. 519). Results: From 2008 until 2015, nine patients with (FUO) caused by C. burnetii were hospitalized at the Military Medical Academy of Sofia. Male gender was predominant (male/female – 77. 8% /22. 2%), mean age was 48. 78± 14. 52 years (range: 26– 67), hospital stay was 9. 78± 2. 95 days (range: 5– 15), Fever duration was 54. 33± 56. 23 days (range: 21– 180). Laboratory investigations estimated the elevation of erythrocyte sedimentation rate 49. 11± 31. 74mm/h (95%CI = 13. 09– 111. 31), C-reactive protein 37. 68± 37. 62mg/L (95% CI = 36. 07– 111. 42) and fibrinogen 5. 69± 1. 59g/L (95% CI=2. 57– 8. 81). The mean values of liver enzymes were in reference range. Among imaging tests, abdominal ultrasound and X-ray demonstrated 33. 3% contribution to the final diagnosis. Transthoracic echocardiography found 22. 2% contribution. Serological methods presented 100% contribution. Conclusion: C. burnetii infection was accepted as a final diagnosis among 9 patients with (FUO) based on the integrated information from the applied methods. Active search and establishment of this pathogen among (FUO) should lead to avoiding potential complications and consequences in case of untreated patients infected with C. burnetii.